"Western diet," as they call it in the nutrition literature, does not mean a high fat diet. It is widely said that association does not imply causality. More accurate is that association does not necessarily imply causality. Few people would deny that the association of dietary calories and body mass is causal, however non-linear the association might be. Whether the association between increased carbohydrate intake and increased calories is causative is one of the themes in this book.
Figure 2-2 . Consumption of macronutrients during the epidemic of obesity and diabetes. Inset: number of people with diabetes. The horizontal axis represents the period in which NHANES ( National Health and Nutrition Examination Survey) collected data. The left vertical axis is the absolute energy input in kcal. The right axis is the % change in calories. The ratios of macronutrient is shown along the top. We also ask whether the inset showing the carbohydrate-diabetes association in Figure 2-2 tells us about what causes what. The argument will be that, given the effectiveness of low-carbohydrate (high-fat) diets as a treatment (sometimes a virtual cure) for diabetes, it would be surprising if carbohydrates were not involved in some way in a causative role. Finally, there is an obvious association between the official advice of the USDA, the AHA and just about everybody else to reduce fat and increase carbohydrates and what people actually did. They reduced fat, at least as a percentage of calories and they dramatically increased carbohydrates. Looking ahead, one way to test whether there is a causal link between carbohydrate intake and obesity, is to simply reduce carbohydrates and see if total caloric intake goes down or, in fact whether diabetes incidence goes down. There are some good experiments that test this. The results are as expected and the details of one experiment are described in Chapter 9. Whatever else can be drawn from these data, the association between increased carbohydrate/decreased fat and obesity and diabetes is the single result that makes the largest impact on our medical students and remains an undercurrent in any analysis of the role of macronutrients. 4. The macronutrient most likely to raise blood glucose in people with type 2 diabetes is: __ X _ Carbohydrate. _____ Protein. _____ Fat. _____ Alcohol. This is, or should be obvious. The correct answer was chosen by 83 % of our students. The surprise is probably that anybody got it wrong. Diabetes is fundamentally a disease (really several diseases) of carbohydrate intolerance. People with type 1 diabetes cannot produce the hormone insulin in response to blood glucose. People with type 2 have progressive deterioration of the insulin-producing beta cells of the pancreas. They do produce insulin but their cells respond poorly. They are said to show insulin resistance. Insulin has effects on many tissues, particularly adipocytes (fat cells). Diabetes is as much a disease of fat metabolism as of carbohydrate metabolism: the primary effect of insulin is on synthesis and breakdown of fat and a person with type 2 diabetes may have excessive fatty acids in their blood. Nonetheless, the most obvious characteristic and the major risk for other symptoms is the hyperglycemia (high blood glucose). Different carbohydrate-containing foods raise blood glucose to different extents but the general principle holds. The dietary requirement for carbohydrate 5. The dietary requirement for carbohydrate is: _____ approximately 130 g/day _____ approximately 50 % of calories _____ as much as possible __ X _ there is no dietary requirement for carbohydrate
Student Performance on Question 5 There is no requirement for dietary carbohydrates as there is for the so-called essential amino acids or essential fatty acids. This does not mean that anybody recommends doing without them altogether even if this were possible (even meat has a small amount of