Coast bias. There’s the added fact that I live in Manhattan. When you live here, you can pretend the rest of the world doesn’t exist.
I can’t do that anymore. What happened yesterday and what happened in Oregon are now so strongly bonded that it feels like Eugene is located right across the Hudson. A reporter named Mike Dermott wrote a huge piece about Oregon last week. I never bothered to read it before now. But I’ve read it a dozen times in the past couple of hours. I can nearly recite it from memory. Copied from Slate :
The Man Who Conquered Death
By Mike Dermott
Graham Otto never set out to conquer death. He was just hoping to help out the redheads of the world.
“I’m a redhead,” he noted in his private journal, to which I was granted exclusive access by the Otto family. “I’ve yet to meet a redheaded guy who enjoys being a redhead.” The name of the gene is MCR1. It’s located on chromosome 16. And according to the complete map of the human genome, it’s the gene that causes red hair (along with a rare condition called brittle cornea syndrome). Working with a team of fellow geneticists, Otto targeted this gene in hopes of finding a way to color hair through gene therapy. “It wasn’t the most noble of genetic experiments,” he wrote. “It was the sort of thing a wealthy university like U. Oregon does from time to time, when it feels like playing around.”
“He was excited about the potential business aspect of it. We all were,” recalls his wife, Sarah. “Frankly, I was just thrilled at the prospect of never having to pay three hundred dollars for highlights ever again.”
He didn’t fit the traditional scientist mold. Otto had attended Oregon on a partial scholarship for track and placed as high as eighth in the two-mile event at the 2000 Prefontaine Classic. He was an outgoing man, who always preferred company while working in the lab and who was always able to talk about his work in ways that laymen found not only accessible but downright fascinating.
“I think that’s what made him such a great teacher,” says UO president Raymond Lack. “He was passionate about his work but not to the point where he became insular. You never felt like he was talking over your head about any of this stuff. He made it sound interesting, even entertaining. And trust me, that’s not a commonplace trait among his peers. His communication skills were a rare gift for anyone, in any profession.”
In terms of changing hair color through gene therapy, Otto was a miserable failure. The problem wasn’t extracting the redhead protein from the gene. That proved easy for Otto and his self-described team of “Hair Bears.” The problem was replacing the color. “If you take away a person’s genetically predisposed color, you essentially give them colorless hair—albino hair,” he wrote. “You have to eliminate that protein in the gene and you have to find a way to add the color of your preference, and that’s where the engineering becomes close to a technical impossibility.” Otto experimented with altering proteins found elsewhere in the DNA helix of fruit flies (who can have red eyes that are triggered by the same gene), trying to activate a different color. “We tried blue. We tried brown. We tried green. Nothing worked.”
Exasperated one night in the lab, Otto became careless. In the midst of deadening the red protein in that day’s batch of flies, he removed an extra protein from the gene as well. “I knew exactly what I had done,” he wrote. “But it was late, and I didn’t feel like starting over. Every good scientist knows that if you contaminate the original sample, you toss it. But I didn’t. I figured it wouldn’t make a difference in the end, so I went ahead and injected the vector. It was pure sloppiness.” When Otto returned the following morning, nothing unusual had occurred. He tried to introduce a new color protein into the flies’ DNA, but it again failed. He
I can’t do that anymore. What happened yesterday and what happened in Oregon are now so strongly bonded that it feels like Eugene is located right across the Hudson. A reporter named Mike Dermott wrote a huge piece about Oregon last week. I never bothered to read it before now. But I’ve read it a dozen times in the past couple of hours. I can nearly recite it from memory. Copied from Slate :
The Man Who Conquered Death
By Mike Dermott
Graham Otto never set out to conquer death. He was just hoping to help out the redheads of the world.
“I’m a redhead,” he noted in his private journal, to which I was granted exclusive access by the Otto family. “I’ve yet to meet a redheaded guy who enjoys being a redhead.” The name of the gene is MCR1. It’s located on chromosome 16. And according to the complete map of the human genome, it’s the gene that causes red hair (along with a rare condition called brittle cornea syndrome). Working with a team of fellow geneticists, Otto targeted this gene in hopes of finding a way to color hair through gene therapy. “It wasn’t the most noble of genetic experiments,” he wrote. “It was the sort of thing a wealthy university like U. Oregon does from time to time, when it feels like playing around.”
“He was excited about the potential business aspect of it. We all were,” recalls his wife, Sarah. “Frankly, I was just thrilled at the prospect of never having to pay three hundred dollars for highlights ever again.”
He didn’t fit the traditional scientist mold. Otto had attended Oregon on a partial scholarship for track and placed as high as eighth in the two-mile event at the 2000 Prefontaine Classic. He was an outgoing man, who always preferred company while working in the lab and who was always able to talk about his work in ways that laymen found not only accessible but downright fascinating.
“I think that’s what made him such a great teacher,” says UO president Raymond Lack. “He was passionate about his work but not to the point where he became insular. You never felt like he was talking over your head about any of this stuff. He made it sound interesting, even entertaining. And trust me, that’s not a commonplace trait among his peers. His communication skills were a rare gift for anyone, in any profession.”
In terms of changing hair color through gene therapy, Otto was a miserable failure. The problem wasn’t extracting the redhead protein from the gene. That proved easy for Otto and his self-described team of “Hair Bears.” The problem was replacing the color. “If you take away a person’s genetically predisposed color, you essentially give them colorless hair—albino hair,” he wrote. “You have to eliminate that protein in the gene and you have to find a way to add the color of your preference, and that’s where the engineering becomes close to a technical impossibility.” Otto experimented with altering proteins found elsewhere in the DNA helix of fruit flies (who can have red eyes that are triggered by the same gene), trying to activate a different color. “We tried blue. We tried brown. We tried green. Nothing worked.”
Exasperated one night in the lab, Otto became careless. In the midst of deadening the red protein in that day’s batch of flies, he removed an extra protein from the gene as well. “I knew exactly what I had done,” he wrote. “But it was late, and I didn’t feel like starting over. Every good scientist knows that if you contaminate the original sample, you toss it. But I didn’t. I figured it wouldn’t make a difference in the end, so I went ahead and injected the vector. It was pure sloppiness.” When Otto returned the following morning, nothing unusual had occurred. He tried to introduce a new color protein into the flies’ DNA, but it again failed. He
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